Amy Andreotti Publications

Associate Professor
Nuclear magnetic resonance
Macromolecular structure and recognition

Selected Publications

Joseph, R.E., Min, L. and Andreotti, A.H. (2007) The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases. Biochemistry 46, 5455-5462.

Joseph, R.E., Min, L., Xu, R., Musselman, E.D. and Andreotti, A.H. (2007) A remote substrate docking mechanism for the tec family tyrosine kinases. Biochemistry 46, 5595-5603.

Huang, Y.H., Grasis, J.A., Miller, A.T., Xu, R., Soonthornvacharin, S., Andreotti, A.H., Tsoukas, C.D., Cooke, M.P. and Sauer, K. (2007) Positive regulation of Itk PH domain function by soluble IP4. Science 316, 886-889.

Pletneva, E.V., Sundd, M., Fulton, D.B. and Andreotti, A.H. (2006) Molecular details of Itk activation by prolyl isomerization and phospholigand binding: the NMR structure of the Itk SH2 domain bound to a phosphopeptide. J. Mol. Biol. 357, 550-561.

Andreotti, A.H. (2006) Opening the pore hinges on proline.  Nat Chem Biol. 2, 13-14.

Venkitaramani, D.V., Fulton, D.B., Andreotti, A.H., Johansen, K.M. and Johansen, J. (2006) Mapping the Ca2+ -dependent binding of an invertebrate homolog of protein phosphatase 4 regulatory subunit 2 to the small EF-hand protein, calsensin. Biochim. Biophys. Acta 1763, 322-329.

Min, L., Fulton, D.B. and Andreotti, A.H. (2005) A case study of proline isomerization in cell signaling. Front. Biosci. 10, 385-397.

Venkitaramani, D.V., Fulton, D.B., Andreotti, A.H., Johansen, K.M. and Johansen, J. (2005) Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein. Protein Sci. 14, 1984-1901.

Colgan, J., Asmal, M., Neagu, M., Yu, B., Schneidkraut, J., Lee, Y., Sokolskaja, E., Andreotti, A.H. and Luban, J. (2004) Cyclophilin A Regulates TCR signal strength in CD4(+) T cells via a proline-directed conformational switch in Itk. Immunity 21, 189-201.

Laederach, A., Cradic, K.W., Fulton, D.B. and Andreotti, A.H. (2003) Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk. J. Mol. Biol. 329, 1011-1020.

Breheny, P.J., Laederach, A., Fulton, D.B. and Andreotti, A.H. (2003) Ligand specificity modulated by prolyl imide bond cis/trans isomerization in the Itk SH2 domain: a quantitative NMR study. J. Am. Chem. Soc. 125, 15706-15707.

Wen, J., Chowdhury, P., Fulton, D.B., Datta, A., Das, K., Andreotti, A.H. and Petrich, J.W. (2003) Does solvent influence the ground-state tautomeric population of hypericin? Photochem. Photobiol. 77, 5-9.

Andreotti, A.H. (2003) Native state proline isomerization: an intrinsic molecular switch. Biochemistry 42, 9515-9524.

Mallis, R.J., Brazin, K.N., Fulton, D.B. and Andreotti, A.H. (2002) Structural characterization of a proline-driven conformational switch within the Itk SH2 domain. Nat. Struct. Biol. 9, 900-905.

Laederach, A., Cradic, K.W., Brazin, K.N., Zamoon, J., Fulton, D.B., Huang, X.Y. and Andreotti, A.H. (2002) Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization. Protein Sci. 11, 36-45.

Laederach, A., Andreotti, A.H. and Fulton, D.B. (2002) Solution and micelle-bound structures of tachyplesin I and its active aromatic linear derivatives. Biochemistry 41, 12359-12368.

Brazin, K.N., Mallis, R.J., Fulton, D.B. and Andreotti, A.H. (2002) Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A. Proc. Natl. Acad. Sci. USA 99, 1899-1904.

Watson, R.M., Woody, R.W., Lewis, R.V., Bohle, D.S., Andreotti, A.H., Ray, B. and Miller, K.W. (2001) Conformational changes in pediocin AcH upon vesicle binding and approximation of the membrane-bound structure in detergent micelles. Biochemistry 40, 14037-14046.

Brazin, K.N., Fulton, D.B. and Andreotti, A.H. (2000) A specific intermolecular association between the regulatory domains of a Tec family kinase. J. Mol. Biol. 302, 607-623.

Kalben, A., Pal, S., Andreotti, A.H., Walker, S., Gange, D., Kaustav, B. and Kahne, D. (2000) Calicheamicin-DNA recognition: An analysis of seven different drug-DNA complexes. J. Am. Chem. Soc. 122, 8403-8412.

Smirnov, A,, Fulton, D.B., Andreotti, A.H. and Petrich, J. (1999) Exploring ground-state heterogeneity of hypericin and hypocrellin: Dynamic and 2D ROESY NMR study. J. Am. Chem. Soc. 121, 7979-7988

Kapoor, T.M., Andreotti, A.H. and Schreiber, S.L. (1998) Exploring the specificity
pockets of two homologous SH3 domains using structure-based, split-pool synthesis and affinity-based selection. J. Am. Chem. Soc. 120, 23-29

Andreotti, A.H., Bunnell, S.C., Feng, S., Berg, L.J. and Schreiber, S.L. (1997) Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature 385, 93-97.

Liang, R., Andreotti, A.H. and Kahne, D. (1995) Sensitivity of glycopeptide conformation to carbohydrate chain length. J. Am. Chem. Soc. 117, 10395-10403.

Andreotti, A.H. and Kahne, D. (1993) Effects of glycosylation on peptide backbone conformation. J. Am. Chem. Soc. 115, 3352-3359.