Associate Professor
Protein structure and function
Heme proteins
X-ray crystallography
Selected Publications
Hargrove, M.S. (2005) Ligand binding with stopped-flow rapid
mixing. Methods Mol. Biol. 305, 323-342.
Trent, J.T., 3rd, Kundu, S., Hoy, J.A. and Hargrove, M.S. (2004) Crystallographic
analysis of synechocystis cyanoglobin reveals the structural changes
accompanying ligand binding in a hexacoordinate hemoglobin. J. Mol.
Biol. 341, 1097-1108.
Weiland, T.R., Kundu, S., Trent, J.T., 3rd, Hoy, J.A. and Hargrove,
M.S. (2004) Bis-histidyl hexacoordination in hemoglobins facilitates
heme reduction kinetics. J. Am. Chem. Soc. 126, 11930-11935.
Hoy, J.A., Kundu, S., Trent, J.T., 3rd, Ramaswamy, S. and Hargrove,
M.S. (2004) The crystal structure of Synechocystis hemoglobin with a
covalent heme linkage. J. Biol. Chem. 279, 16535-16542.
Chowdhury, P.K., Halder, M., Sanders, L., Arnold, R.A., Liu, Y., Armstrong,
D.W., Kundu, S., Hargrove, M.S., Song, X. and Petrich, J.W. (2004) The
complex of apomyoglobin with the fluorescent dye coumarin 153. Photochem.
Photobiol. 79, 440-446.
Kundu, S., Blouin, G.C., Premer, S.A., Sarath, G., Olson, J.S. and Hargrove,
M.S. (2004) Tyrosine B10 inhibits stabilization of bound carbon monoxide
and oxygen in soybean leghemoglobin. Biochemistry 43, 6241-6252.
Kundu, S. and Hargrove, M.S. (2003) Distal heme pocket regulation of
ligand binding and stability in soybean leghemoglobin. Proteins
50, 239-248.
Kundu, S., Premer, S.A., Hoy, J.A., Trent, J.T., 3rd and Hargrove, M.S.
(2003) Direct measurement of equilibrium constants for high-affinity
hemoglobins. Biophys. J. 84, 3931-3940.
Kundu, S., Trent, J.T., 3rd and Hargrove, M.S. (2003) Plants, humans
and hemoglobins. Trends Plant Sci. 8, 387-393.
Trent, J.T., 3rd and Hargrove, M.S. (2002) A ubiquitously expressed
human hexacoordinate hemoglobin. J. Biol. Chem. 277, 19538-19545.
Kundu, S., Snyder, B., Das, K., Chowdhury, P., Park, J., Petrich, J.W.
and Hargrove, M.S. (2002) The leghemoglobin proximal heme pocket directs
oxygen dissociation and stabilizes bound heme. Proteins 46,
268-277.
Watts, R.A., Hunt, P.W., Hvitved, A.N., Hargrove, M.S., Peacock, W.J.
and Dennis, E.S. (2001) A hemoglobin from plants homologous to truncated
hemoglobins of microorganisms. Proc. Natl. Acad. Sci. USA 98,
10119-10124.
Trent, J.T., 3rd, Hvitved, A.N. and Hargrove, M.S. (2001) A model for
ligand binding to hexacoordinate hemoglobins. Biochemistry
40, 6155-6163.
Trent, J.T., 3rd, Watts, R.A. and Hargrove, M.S. (2001) Human neuroglobin,
a hexacoordinate hemoglobin that reversibly binds oxygen. J. Biol.
Chem. 276, 30106-30110.
Hvitved, A.N., Trent, J.T., 3rd, Premer, S.A. and Hargrove, M.S. (2001)
Ligand binding and hexacoordination in synechocystis hemoglobin. J.
Biol. Chem. 276, 34714-34721.
Goodman, M.D. and Hargrove, M.S. (2001) Quaternary structure of rice
nonsymbiotic hemoglobin. J. Biol. Chem. 276, 6834-6839.
Hargrove, M.S., Brucker, E.A., Stec, B., Sarath, G., Arredondo-Peter,
R., Klucas, R.V., Olson, J.S. and Phillips, G.N., Jr. (2000) Crystal
structure of a nonsymbiotic plant hemoglobin. Structure Fold. Des.
8, 1005-1014.
Hargrove, M.S. (2000) A flash photolysis method to characterize hexacoordinate
hemoglobin kinetics. Biophys. J. 79, 2733-2738.
