Professor
Structure determination of macromolecules of biological interest
Crystallization of proteins and x-ray crystallography
Energy-conformation analysis of protein ligand interactions
Selected Publications
Hines, J. K., Fromm, H. J., and Honzatko, R. B. (2007) Structures of activated fructose-1,6-bisphosphatase from Escherichia coli. J. Biol. Chem. 282, 11696-11704.
Iancu, C. V. Zhou, Y., Borza, T., Fromm, H. J., and Honzatko, R. B. (2006) Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases. Biochemistry 45, 11703-11711.
Hines, J. K., Fromm, H. J., and Honzatko, R. B. (2006) Novel allosteric activation site in E. coli fructose-1,6-bisphosphatase. J. Biol. Chem. 281, 18386-18393.
Ginder, N. D., Binkowski, D. J., Fromm, H. J., and Honzatko, R. B. (2006) Nucleotide complexes of Escherichia coli phosphoribosyl-aminoimidazole-succinocarboxamide synthetase. J. Biol. Chem. 281, 20680-20688.
Lee, J. -H., Kang, H. -K., Moon, Y. -H., Cho, D. L., Kim, D., Choe, J. -Y., Honzatko, R. B., and Robyt, J. F. (2006) Cloning, characterization, and crystallization of an extracellular enolase from Leuconostoc mesenteroides. FEMS Microbiol. Lett. 259, 240-248.
Skaff, D.A., Kim, C.S., Tsai, H.J., Honzatko, R.B. and Fromm,
H.J. (2005) Glucose 6-phosphate release of wild-type and mutant human
brain hexokinases from mitochondria. J. Biol. Chem. 280, 38403-38409.
Iancu, C. V., Mukund, S., Fromm, H. J., and Honzatko, R. B. (2005) R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatease. J. Biol. Chem. 280, 19737-19745.
Nelson, S. W, Binkowski, D. J., Honzatko, R. B., and Fromm, H. J. (2005) Mechanism of action of Esherichia coli phosphoribosylaminoimidazolesuccinocarboxamide Synthetase. Biochemistry 44, 766–774.
Nelson, S. W., Honzatko, R. B., and Fromm, H. J., (2004) Origin of cooperativity in the activation of fructose-1,6-bisphosphatase by Mg2+. J. Biol. Chem. 279, 18481-7.
Choe J-Y., Nelson, S. W., Fromm, H. J., and Honzatko, R. B. (2003) Inhibition of fructose-1,6-bisphosphatase by a new class of allosteric effectors. J. Biol. Chem. 278, 16008-14.
Choe J-Y., Nelson, S. W., Fromm, H. J., and Honzatko, R. B. (2003) Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase. J. Biol. Chem. 278, 16008-14.
Choe J-Y., Iancu, C. V., Fromm, H. J., and Honzatko, R. B. (2003) Metaphosphate in the active site of fructose-1,6-bisphosphatase. J. Biol. Chem. 278, 16015-20.
Borza, T., Iancu, C. V., Pike, E., Honzatko, R. B., and Fromm, H. J. (2003) Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance, J. Biol. Chem. 278, 6673-79.
Aleshin, A. E., Feng, P.-H. Honzatko, R. B., and Reilly, P. J. (2003) Crystal structure of a prokaryotic glucoamylase. J. Mol. Biol. 327, 61-73.
.
