Professor
Regulation of nuclear organization and function
Selected Publications
Johansen, K.M and J. Johansen (2007) Cell and molecular biology of the spindle matrix. Int. Rev. Cytol. In press.
Bao, X., J. Girton, J. Johansen and K.M. Johansen (2007) The lamin Dm0Ari3 allele acts as an enhancer of position effect variegation at the wm4 locus in Drosophila. Genetica 129 : 339-342.
Lerach, S., W. Zhang, X. Bao, H. Deng, J. Girton, J. Johansen and K.M. Johansen (2006) Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect varigation of the wm4 allele in Drosophila. Genetics 173 : 2403-2406.
Johansen, K.M. and J. Johansen (2006) Regulation of chromatin structure by histone H3S10 phosphorylation. Chromosome Res. 14 : 393-404.
Rath, U., Y. Ding, H. Deng, H. Qi, X. Bao, W. Zhang, J. Girton, J. Johansen, and K.M. Johansen (2006) The chromodomain protein, Chromator, interacts with JIL-1 kinase and regulates the structure of Drosophila polytene chromosomes. J. Cell Sci. 119 : 2332-2341.
Zhang, W., H. Deng, X. Bao, S. Lerach, J. Girton, J. Johansen and K.M. Johansen (2006) The JIL-1 histone H3S10 kinase regulates dimethyl histone H3K9 modifications and heterochromatic spreading in Drosophila. Development 133 : 229-235.
Lerach, S., W. Zhang, H. Deng, X. Bao, J. Girton, J. Johansen and K.M. Johansen (2005) The JIL-1 kinase, a member of the MSL complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila. Genesis 43 : 213-215.
Bao, X., Zhang, W., Krencik, R., Deng, H., Wang, Y., Girton, J., Johansen,
J. and Johansen, K.M. (2005) The JIL-1 kinase interacts with lamin Dm0
and regulates nuclear lamina morphology of Drosophila nurse cells. J.
Cell Sci. 118, 5079-5087.
Qi, H., Rath, U., Ding, Y., Ji, Y., Blacketer, M.J., Girton, J., Johansen,
J., and Johansen, K.M. (2005) EAST interacts with Megator and localizes
to the putative spindle matrix during mitosis in Drosophila. J.
Cell. Biochem. 95, 1284-1291.
Ji, Y., Rath, U., Girton, J., Johansen, K.M. and Johansen, J. (2005)
D-Hillarin, a novel W180-domain protein, affects cytokinesis through
interaction with the septin family member Pnut. J. Neurobiol.
64, 157-169.
Venkitaramani, D.V., Fulton, D.B., Andreotti, A.H., Johansen, K.M. and
Johansen, J. (2005) Solution structure and backbone dynamics of Calsensin,
an invertebrate neuronal calcium-binding protein. Protein Sci.
14, 1984-1901.
Rath, U., Wang, D., Ding, Y., Xu, Y.Z., Qi, H., Blacketer, M.J., Girton,
J., Johansen, J. and Johansen, K.M. (2004) Chromator, a novel and essential
chromodomain protein interacts directly with the putative spindle matrix
protein skeletor. J. Cell. Biochem. 93, 1033-1047.
Qi, H., Rath, U., Wang, D., Xu, Y.Z., Ding, Y., Zhang, W., Blacketer,
M.J., Paddy, M.R., Girton, J., Johansen, J. and Johansen, K.M. (2004)
Megator, an essential coiled-coil protein that localizes to the putative
spindle matrix during mitosis in Drosophila. Mol. Biol. Cell 15, 4854-4865.
Venkitaramani, D.V., Wang, D., Ji, Y., Xu, Y.Z., Ponguta, L., Bock,
K., Zipser, B., Jellies, J., Johansen, K.M. and Johansen, J. (2004)
Leech filamin and tractin: markers for muscle development and nerve
formation. J. Neurobiol. 60, 369-380.
Johansen, K.M. and Johansen, J. (2004) Studying nuclear organization
in embryos using antibody tools. Methods Molec. Biol. 247,
215-234.
Zhang, W., Wang, Y., Long, J., Girton, J., Johansen, J. and Johansen,
K.M. (2003) A developmentally regulated splice variant from the complex
lola locus encoding multiple different zinc finger domain proteins interacts
with the chromosomal kinase JIL-1. J. Biol. Chem. 278, 11696-11704.
Zhang, W., Jin, Y., Ji, Y., Girton, J., Johansen, J. and Johansen, K.M.
(2003) Genetic and phenotypic analysis of alleles of the Drosophila
chromosomal JIL-1 kinase reveals a functional requirement at multiple
developmental stages. Genetics 165, 1341-1354.
Xu, Y.Z., Ji, Y., Zipser, B., Jellies, J., Johansen, K.M. and Johansen,
J. (2003) Proteolytic cleavage of the ectodomain of the L1 CAM family
member Tractin. J. Biol. Chem. 278, 4322-4330.
Johansen, K.M. and Johansen, J. (2002) Recent glimpses of the elusive
spindle matrix. Cell Cycle 1, 312-314.
Wang, Y., Zhang, W., Jin, Y., Johansen, J. and Johansen, K.M. (2001)
The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required
for maintenance of chromatin structure in Drosophila. Cell 105,
433-443.
Ji, Y., Schroeder, D., Byrne, D., Zipser, B., Jellies, J., Johansen,
K.M. and Johansen, J. (2001) Molecular identification and sequence analysis
of Hillarin, a novel protein localized at the axon hillock. Biochim.
Biophys. Acta 1519, 246-249.
Jin, Y., Wang, Y., Johansen, J. and Johansen, K.M. (2000) JIL-1, a chromosomal
kinase implicated in regulation of chromatin structure, associates with
the male specific lethal (MSL) dosage compensation complex. J. Cell
Biol. 149, 1005-1010.
Walker, D.L., Wang, D., Jin, Y., Rath, U., Wang, Y., Johansen, J. and
Johansen, K.M. (2000) Skeletor, a novel chromosomal protein that redistributes
during mitosis provides evidence for the formation of a spindle matrix.
J. Cell Biol. 151, 1401-1412.
Jie, C., Xu, Y., Wang, D., Lukin, D., Zipser, B., Jellies, J., Johansen,
K.M. and Johansen, J. (2000) Posttranslational processing and differential
glycosylation of Tractin, an Ig-superfamily member involved in regulation
of axonal outgrowth. Biochim. Biophys. Acta 1479, 1-14.
Jellies, J., Johansen, K.M. and Johansen, J. (2000) Ectopic CNS projections
guide peripheral neuron axons along novel pathways in leech embryos. Dev. Biol. 218, 137-145.
Jin, Y., Wang, Y., Walker, D.L., Dong, H., Conley, C., Johansen, J.
and Johansen, K.M. (1999) JIL-1: a novel chromosomal tandem kinase implicated
in transcriptional regulation in Drosophila. Mol. Cell 4, 129-135.
Xu, Y., Bolton, B., Zipser, B., Jellies, J., Johansen, K.M. and Johansen,
J. (1999) Gliarin and macrolin, two novel intermediate filament proteins
specifically expressed in sets and subsets of glial cells in leech central
nervous system. J. Neurobiol. 40, 244-253.
Weiss, J.L., Yang, J., Jie, C., Walker, D.L., Ahmed, S., Zhu, Y., Huang,
Y., Johansen, K.M. and Johansen, J. (1999) Molecular cloning and characterization
of LKv1, a novel voltage-gated potassium channel in leech. J. Neurobiol.
38, 287-299.
Jie, C., Zipser, B., Jellies, J., Johansen, K.M. and Johansen, J. (1999)
Differential glycosylation and proteolytical processing of LeechCAM
in central and peripheral leech neurons. Biochim. Biophys. Acta 1452, 161-171.
Huang, Y., Jellies, J., Johansen, K.M. and Johansen, J. (1998) Development
and pathway formation of peripheral neurons during leech embryogenesis. J. Comp. Neurol. 397, 394-402.
Johansen, J. and Johansen, K.M. (1997) Molecular mechanisms mediating
axon pathway formation. Crit. Rev. Eukaryot. Gene Expr. 7,
95-116.
Huang, Y., Jellies, J., Johansen, K.M. and Johansen, J. (1997) Differential
glycosylation of tractin and LeechCAM, two novel Ig superfamily members,
regulates neurite extension and fascicle formation. J. Cell Biol.
138, 143-157.
Johansen, K.M., Johansen, J., Baek, K.H. and Jin, Y. (1996) Remodeling
of nuclear architecture during the cell cycle in Drosophila embryos.
J. Cell. Biochem. 63, 268-279.
Veldman, M., Huang, Y., Jellies, J., Johansen, K.M. and Johansen, J.
(1996) Differential expression of the EF-hand calcium-binding protein
calsensin in the central nervous system of hirudinid leeches. Cell
Tissue Res. 286, 357-364.
Jellies, J., Kopp, D.M., Johansen, K.M. and Johansen, J. (1996) Initial
formation and secondary condensation of nerve pathways in the medicinal
leech. J. Comp. Neurol. 373, 1-10.
Johansen, K.M. and Johansen, J. (1995) Filarin, a novel invertebrate
intermediate filament protein present in axons and perikarya of developing
and mature leech neurons. J. Neurobiol. 27, 227-239.
Jellies, J., Johansen, K.M. and Johansen, J. (1995) Peripheral neurons
depend on CNS-derived guidance cues for proper navigation during leech
development. Dev. Biol. 171, 471-482.
Briggs, K.K., Silvers, A.J., Johansen, K.M. and Johansen, J. (1995)
Calsensin: a novel calcium-binding protein expressed in a subset of
peripheral leech neurons fasciculating in a single axon tract. J.
Cell Biol. 129, 1355-1362.
