Anant Menon Seminar

Thursday, February 7, 2019 - 4:10pm to 5:00pm
Event Type: 

Department of Biochemistry - Weill Cornell Medical College


Host:  Eric Underbakke


"Flipping Lipids Across Membranes"

Transferring a lipid from one side of a membrane bilayer to the other side is energetically expensive and occurs rarely.  Yet lipid flipping is critical for cellular life. In metazoa, it is required for cellular growth and - surprisingly - for post-translational modifications of secretory proteins such as N-glycosylation, O-mannosylation and GPI-anchoring. 

In this lecture I will describe work that led to the discovery of a surprising phospholipid scramblase, a membrane protein capable of exchanging phospholipids between the two leaflets of a bilayer at a tremendous rate.  I will also describe what we know about the molecular mechanism of this process.