*** CANCELLED*** BBMB Seminar - Order from chaos: how unstructured proteins control RNA decay

Thursday, March 26, 2020 - 4:10pm to 5:00pm


Speaker: Dr John Gross, Professor - Department of Pharmaceutical Chemistry, University of California-San Francisco

Title: Order from chaos: how unstructured proteins control RNA decay

Abstract: Our lab is interested in RNA biology, specifically control of mRNA decay in normal and virally infected cells.   Removal of the mRNA cap structure is a critical step in RNA degradation pathways, which are controlled by a dense network of protein-protein interactions.  Processing enzymes and cofactors are replete with intrinsically disordered regions that are required to promote the degradation of thousands of mRNAs in cells.  I will present recent work on the conformational control of mRNA decapping by Dcp2 and show how intrinsically disordered regions can couple regulatory conformational changes to the formation of biological condensates.