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VERSION:2.0
PRODID:-//Iowa State University CALS LAS Web Team//sites.iastate.edu//EN
BEGIN:VEVENT
UID:20221207T150000-534-www.bbmb.iastate.edu
DTSTART:20221207T150000Z
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20221207T160000Z
SUMMARY:Sahiba Siddiqui - Mechanism of Fyn kinase-mediated microglia activa
 tion and inflammatory associated neurodegeneration
CLASS:PUBLIC
DESCRIPTION:Abstract: &nbsp\;&nbsp\;Cellular kinases play a central role in
  protein aggregation in dementia and neurodegeneration and their involveme
 nt in inflammatory signaling in Alzheimer’s Disease (AD) and related neu
 rodegenerative diseases (ADRD) is now emerging. The Src family member Fyn 
 kinase mediates AD amyloid b and tau protein pathophysiology. More recentl
 y Fyn was identified as a Parkinson’s Disease (PD) risk locus and in vit
 ro has been shown to regulate microglia PKC-d/NF-kb inflammatory signaling
  in response to a-synuclein aggregate uptake. While protein aggregation an
 d microglia activation reinforce neuroinflammation\, the cellular mechanis
 m at the intersection of these pathways is incompletely understood.\n\nMor
 e information at: https://www.bbmb.iastate.edu/event/2022/sahiba-siddiqui-
 mechanism-fyn-kinase-mediated-microglia-activation-and-inflammatory
DTSTAMP:20260516T111845Z
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