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VERSION:2.0
PRODID:-//Iowa State University CALS LAS Web Team//sites.iastate.edu//EN
BEGIN:VEVENT
UID:20241016T140000-675-www.bbmb.iastate.edu
DTSTART:20241016T140000Z
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20241016T150000Z
SUMMARY:BBMB BIOWIP Seminar\, Dilini Dissanayake - Toward the characterizat
 ion of functional dynamics in the Human Alkbh1 enzyme
CLASS:PUBLIC
DESCRIPTION:Abstract:&nbsp\;Human Alkbh1 is a member of the AlkB family of 
 proteins. Like other AlkB family proteins\, hAlkbh1 is a Fe2+&nbsp\;and al
 pha-ketoglutarate-dependent dioxygenase that catalyzes oxidative demethyla
 tion of modified nucleotides and amino acids. hAlkbh1 shows activity again
 st six different substrates such as the m6A in ssDNA/ bulge or bubble DNA\
 , m3C in DNA/RNA\, methylated lysine in histone H2A\, m1A in mitochondrial
  tRNA for the demethylation\, oxidation of m5C in mitochondrial tRNA and l
 yase cleavage of AP sites in DNA. Also\, hAlkbh1 has significant involveme
 nt in many cancers\, metastasis\, developmental defects\, hypothermia\, et
 c.\n\nMore information at: https://www.bbmb.iastate.edu/event/2024/bbmb-bi
 owip-seminar-dilini-dissanayake-toward-characterization-functional-dynamic
 s-human
DTSTAMP:20260516T121025Z
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