College of Biological Sciences – BioTechnology Institute
University of Minnesota
"Exquisite Molecular Specificity: the Importance of a Short Hydrogen Bond in Bacterial Phosphate Transport"
Arsenate and phosphate are abundant on our planet and exhibit tremendous similarities: nearly identical pKa values, similarly charged oxygen atoms, and thermochemical radii that differ by only 4%. However, phosphate is indispensable whereas arsenate is toxic. Can proteins discriminate between these two anions, and how would they do so?