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Welcome to our Group

Research in the Nikolau Group is focused on the comprehensive understanding of metabolism. The lab is particularly focused on the discovery and characterization of novel metabolic processes, and the associated biocatalysts, utilizing expanding genomics resources as the starting point for these endeavors. Read more about Welcome to our Group

Dr. Basil Nikolau

Basil Nikolau
Principal Investigator
Frances M Craig Professor, Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology (BBMB)
Director, Center for Metabolic Biology
Director, W.M. Keck Metabolomic Research Laboratory
Deputy Director, NSF Engineering Research Center for Biorenewable Chemicals (CBiRC)
Area of Expertise: 
Metabolomics, Metabolism

Biotin metabolic network

Biotin is a water-soluble vitamin that is biosynthesized by plants, and some bacteria and fungi.  One of its biochemical functions is as a covalently-bound cofactor on a family of enzymes that catalyze reactions in a variety of crucial metabolic processes. Examples of such enzymes are acetyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase and geranoyl-CoA carboxylase, which are required for lipogenesis, amino acid metabolism and isoprenoid metabolism. Read more about Biotin metabolic network