Publication Type:Journal Article
Source:Molecules, Volume 13, Number 4, p.986-94 (2008)
ISBN:1420-3049 (Electronic)<br/>1420-3049 (Linking)
Keywords:Cell Line, Fluorine/chemistry/*toxicity, Humans, Rosaniline Dyes/*chemical synthesis/chemistry/*toxicity, Saccharomyces cerevisiae/drug effects, Spectrum Analysis
<p>A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.</p>
Kraus, George A<br/>Jeon, Insik<br/>Nilsen-Hamilton, Marit<br/>Awad, Ahmed M<br/>Banerjee, Jayeeta<br/>Parvin, Bahram<br/>Switzerland<br/>Basel, Switzerland<br/>Molecules. 2008 Apr 27;13(4):986-94.