Julien Roche

People
Assistant Professor
Julien Roche

The research projects in my group are focused on the study of protein folding, design and evolution using solution Nuclear Magnetic Resonance spectroscopy and a variety of complementary biophysical methods. How does a protein fold into it specific tridimensional structure and evolve to perform a given biological function remain key questions in most modern day diseases. Especially when combined with high-pressure perturbation, NMR spectroscopy offers the opportunity to characterize protein free-energy landscapes at an atomic resolution.

Related projects include the study of intrinsically disordered proteins, the characterization of amyloid-type peptides and the development of coarse-grained methods for protein folding simulations.

Area of Expertise: 
Solution NMR of proteins
Education: 
B.S., Biology – University of Montpellier, France
M.S., Biophysics – University of Montpellier, France
Ph.D., Center for Structural Biology, Montpellier, France
Postdoctoral fellow, National Institutes of Health, NIDDK (Dr. Ad Bax), Bethesda, MD.
Contact
515-294-6437
3116 Molecular Bio
Ames
Iowa
50011