Publications
Submitted.
“Blocking Deprotonation with Retention of Aromaticity in a Plant ent-Copalyl Diphosphate Synthase Leads to Product Rearrangement”, Angew Chem Int Ed Eng, vol. 55, no. 2, pp. 634-638, 2016.
, “Characterization of CYP71Z18 indicates a role in maize zealexin biosynthesis”, Phytochemistry, vol. 121, pp. 4-10, 2016.
, “Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones”, New Phytol, vol. in press, 2016.
, “Probing the promiscuity of ent-kaurene oxidase via combinatorial biosynthesis”, Proc Natl Acad Sci U S A, vol. in press, 2016.
, “A tandem array of ent-kaurene synthases in maize with roles in gibberellin and more specialized metabolism”, Plant Physiol, vol. in press, 2016.
, “The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism”, Mol Plant, vol. 8, pp. 6-16, 2015.
, “Biosynthesis of the Diterpenoid Lycosantalonol via Nerylneryl Diphosphate in Solanum lycopersicum”, PLoS One, vol. 10, p. e0119302, 2015.
, “Efficient heterocyclisation by (di)terpene synthases”, Chem Commun (Camb), vol. 51, no. 70, pp. 13485-7, 2015.
, “An ent-kaurene-derived diterpenoid virulence factor from Xanthomonas oryzae pv. oryzicola”, New Phytol, vol. 206, pp. 295-302, 2015.
, “Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis”, Plant J, vol. 82, pp. 951-61, 2015.
, “Funcation divergence of diterpene synthases in the medicinal plant Salvia miltiorrhiza Bunge”, Plant Physiol, vol. 169, pp. 1607-1618, 2015.
, “Investigation of terpene diversification across multiple sequenced plant genomes”, Proc Natl Acad Sci U S A, vol. 112, pp. E81-8, 2015.
, “Investigation of the Chemical Interface in the Soybean-Aphid and Rice-Bacteria Interactions Using MALDI-Mass Spectrometry Imaging”, Anal Chem, vol. 87, no. 10, pp. 5294-5301, 2015.
, “Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis”, Appl Microbiol Biotechnol, vol. 99, no. 18, 2015.
, “1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis”, Biochimica et Biophysica Acta (BBA), vol. 1840, no. 1, pp. 184-190, 2014.
, “Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization”, Phytochemistry, vol. 103, pp. 13-21, 2014.
, “Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins”, The Plant Journal, vol. 79, no. 4, pp. 659-678, 2014.
, “Biosynthesis of lycosantalonol, a cis-prenyl derived diterpenoid”, J Am Chem Soc, vol. 136, pp. 16951-3, 2014.
, “Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola”, Journal of natural products, vol. 77, no. 9, pp. 2144-2147, 2014.
, “Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza”, BMC genomics, vol. 15, no. 1, p. 73, 2014.
, “Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia”, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014.
, “Novel Product Chemistry from Mechanistic Analysis of ent‐Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis”, Angewandte Chemie International Edition, vol. 53, pp. 7198-7202, 2014.
, “To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism”, Annual review of plant biology, vol. 65, pp. 259-286, 2014.
, “Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae”, Organic & biomolecular chemistry, vol. 11, no. 44, pp. 7650-7652, 2013.
, “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts”, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.
, “Gibberellin phytohormone metabolism”, in Isoprenoid Synthesis in Plants and Microorganisms, Springer New York, 2013, pp. 233-249.
, “Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis”, Biochemical Journal, vol. 454, no. 2, pp. 209-216, 2013.
, “The role of momilactones in rice allelopathy”, Journal of chemical ecology, vol. 39, no. 2, pp. 175-185, 2013.
, “Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster”, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.
, “CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism”, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.
, “Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry”, Journal of the American Chemical Society, vol. 134, no. 28, pp. 11369-11371, 2012.
, “Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria”, Frontiers in microbiology, vol. 3, 2012.
, “Functional characterization of wheat copalyl diphosphate synthases sheds light on the early evolution of labdane-related diterpenoid metabolism in the cereals”, Phytochemistry, vol. 84, pp. 40-46, 2012.
, “Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals”, Phytochemistry, vol. 84, pp. 47-55, 2012.
, “Genetic evidence for natural product‐mediated plant–plant allelopathy in rice (Oryza sativa)”, New Phytologist, vol. 193, no. 3, pp. 570-575, 2012.
, “Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis”, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6840-6850, 2012.
, “Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis”, Med. Chem. Commun., vol. 3, no. 8, pp. 899-904, 2012.
, “A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase”, Organic letters, vol. 14, no. 23, pp. 5828-5831, 2012.
, “Terpenoid synthase structures: a so far incomplete view of complex catalysis”, Natural product reports, vol. 29, no. 10, pp. 1153-1175, 2012.
, “CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice”, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
, “Diterpenoid biopolymers: new directions for renewable materials engineering”, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011.
, “Domain loss has independently occurred multiple times in plant terpene synthase evolution”, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011.
, “Electrostatic effects on (di)terpene synthase product outcome”, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011.
, “Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals”, Biochem. J, vol. 435, pp. 589-595, 2011.
, “Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis”, Molecular microbiology, vol. 79, no. 6, pp. 1594-1601, 2011.
, “A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii”, ChemBioChem, vol. 12, no. 13, pp. 1984-1987, 2011.
, “Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7”, FEBS letters, vol. 585, no. 21, pp. 3446-3451, 2011.
, “Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis”, FEBS letters, vol. 585, no. 3, pp. 549-554, 2011.
, “Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase”, Nature chemical biology, vol. 7, no. 7, pp. 431-433, 2011.
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