Publications

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2014
M. Köksal, Potter, K., Peters, R. J., and Christianson, D. W., 1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis, Biochimica et Biophysica Acta (BBA), vol. 1840, no. 1, pp. 184-190, 2014.
A. J. Jackson, Hershey, D. M., Chesnut, T., Xu, M., and Peters, R. J., Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization, Phytochemistry, vol. 103, pp. 13-21, 2014.
E. A. Schmelz, Huffaker, A., Sims, J. W., Christensen, S. A., Lu, X., Okada, K., and Peters, R. J., Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins, The Plant Journal, vol. 79, no. 4, pp. 659-678, 2014.
M. Xu, Hillwig, M. L., Lane, A. L., Tiernan, M. S., Moore, B. S., and Peters, R. J., Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola, Journal of natural products, vol. 77, no. 9, pp. 2144-2147, 2014.
D. M. Hershey, Lu, X., Zi, J., and Peters, R. J., Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014.
K. Potter, Criswell, J., Zi, J., Stubbs, A., and Peters, R. J., Novel Product Chemistry from Mechanistic Analysis of ent‐Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis, Angewandte Chemie International Edition, vol. 53, pp. 7198-7202, 2014.
J. Zi, Mafu, S., and Peters, R. J., To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism, Annual review of plant biology, vol. 65, pp. 259-286, 2014.
2013
J. Zi and Peters, R. J., Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae, Organic & biomolecular chemistry, vol. 11, no. 44, pp. 7650-7652, 2013.
J. Guo, Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., and Chen, X., CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.
R. J. Peters, Gibberellin phytohormone metabolism, in Isoprenoid Synthesis in Plants and Microorganisms, Springer New York, 2013, pp. 233-249.
H. Kato-Noguchi and Peters, R. J., The role of momilactones in rice allelopathy, Journal of chemical ecology, vol. 39, no. 2, pp. 175-185, 2013.
2012
Q. Wang, Hillwig, M. L., Okada, K., Yamazaki, K., Wu, Y., Swaminathan, S., Yamane, H., and Peters, R. J., Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.
Q. Wang, Hillwig, M. L., Wu, Y., and Peters, R. J., CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.
L. Zu, Xu, M., Lodewyk, M. W., Cane, D. E., Peters, R. J., and Tantillo, D. J., Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry, Journal of the American Chemical Society, vol. 134, no. 28, pp. 11369-11371, 2012.
F. M. Mann, Xu, M., Davenport, E. K., and Peters, R. J., Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria, Frontiers in microbiology, vol. 3, 2012.
K. Zhou, Gao, Y., Hoy, J. A., Mann, F. M., Honzatko, R. B., and Peters, R. J., Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6840-6850, 2012.
F. M. Mann and Peters, R. J., Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis, Med. Chem. Commun., vol. 3, no. 8, pp. 899-904, 2012.
J. Criswell, Potter, K., Shephard, F., Beale, M. H., and Peters, R. J., A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase, Organic letters, vol. 14, no. 23, pp. 5828-5831, 2012.
Y. Gao, Honzatko, R. B., and Peters, R. J., Terpenoid synthase structures: a so far incomplete view of complex catalysis, Natural product reports, vol. 29, no. 10, pp. 1153-1175, 2012.
2011
Q. Wang, Hillwig, M. L., and Peters, R. J., CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
M. L. Hillwig, Mann, F. M., and Peters, R. J., Diterpenoid biopolymers: new directions for renewable materials engineering, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011.
M. L. Hillwig, Xu, M., Toyomasu, T., Tiernan, M. S., Wei, G., Cui, G., Huang, L., and Peters, R. J., Domain loss has independently occurred multiple times in plant terpene synthase evolution, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011.
K. Zhou and Peters, R. J., Electrostatic effects on (di)terpene synthase product outcome, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011.
F. M. Mann, VanderVen, B. C., and Peters, R. J., Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis, Molecular microbiology, vol. 79, no. 6, pp. 1594-1601, 2011.
S. Mafu, Hillwig, M. L., and Peters, R. J., A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii, ChemBioChem, vol. 12, no. 13, pp. 1984-1987, 2011.
Y. Wu, Hillwig, M. L., Wang, Q., and Peters, R. J., Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7, FEBS letters, vol. 585, no. 21, pp. 3446-3451, 2011.
F. M. Mann, Thomas, J. A., and Peters, R. J., Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis, FEBS letters, vol. 585, no. 3, pp. 549-554, 2011.
M. Köksal, Hu, H., Coates, R. M., Peters, R. J., and Christianson, D. W., Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase, Nature chemical biology, vol. 7, no. 7, pp. 431-433, 2011.
2009
F. M. Mann, Prisic, S., Hu, H., Xu, M., Coates, R. M., and Peters, R. J., Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis IMPLICATIONS FOR TUBERCULOSIS, Journal of Biological Chemistry, vol. 284, no. 35, pp. 23574-23579, 2009.
S. Swaminathan, Morrone, D., Wang, Q., D Fulton, B., and Peters, R. J., CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.
F. M. Mann, Xu, M., Chen, X., D Fulton, B., Russell, D. G., and Peters, R. J., Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis, Journal of the American Chemical Society, vol. 131, no. 48, pp. 17526-17527, 2009.
W. Gao, Hillwig, M. L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B., and Peters, R. J., A functional genomics approach to tanshinone biosynthesis provides stereochemical insights, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.
D. Morrone, Chambers, J., Lowry, L., Kim, G., Anterola, A., Bender, K., and Peters, R. J., Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum, FEBS letters, vol. 583, no. 2, pp. 475-480, 2009.
K. Zhou and Peters, R. J., Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants, Phytochemistry, vol. 70, no. 3, pp. 366-369, 2009.
2007
A. Roy, Roberts, F. G., P Wilderman, R., Zhou, K., Peters, R. J., and Coates, R. M., 16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana, Journal of the American Chemical Society, vol. 129, no. 41, pp. 12453-12460, 2007.
M. Xu, P Wilderman, R., and Peters, R. J., Following evolution's lead to a single residue switch for diterpene synthase product outcome, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007.
M. Xu, P Wilderman, R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N. M., Coates, R. M., and Peters, R. J., Functional characterization of the rice kaurene synthase-like gene family, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007.
A. Cyr, P Wilderman, R., Determan, M., and Peters, R. J., A modular approach for facile biosynthesis of labdane-related diterpenes, Journal of the American Chemical Society, vol. 129, no. 21, pp. 6684-6685, 2007.
S. Prisic, Xu, J., Coates, R. M., and Peters, R. J., Probing the role of the DXDD motif in class II diterpene cyclases, ChemBioChem, vol. 8, no. 8, pp. 869-874, 2007.
R. P Wilderman and Peters, R. J., A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase, Journal of the American Chemical Society, vol. 129, no. 51, pp. 15736-15737, 2007.
S. Prisic and Peters, R. J., Synergistic substrate inhibition of ent-copalyl diphosphate synthase: a potential feed-forward inhibition mechanism limiting gibberellin metabolism, Plant physiology, vol. 144, no. 1, pp. 445-454, 2007.

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