Publications

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F. M. Mann, Prisic, S., Hu, H., Xu, M., Coates, R. M., and Peters, R. J., Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis IMPLICATIONS FOR TUBERCULOSIS, Journal of Biological Chemistry, vol. 284, no. 35, pp. 23574-23579, 2009.
M. Xu, Hillwig, M. L., Lane, A. L., Tiernan, M. S., Moore, B. S., and Peters, R. J., Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola, Journal of natural products, vol. 77, no. 9, pp. 2144-2147, 2014.
J. Zi and Peters, R. J., Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae, Organic & biomolecular chemistry, vol. 11, no. 44, pp. 7650-7652, 2013.
Q. Wang, Hillwig, M. L., Okada, K., Yamazaki, K., Wu, Y., Swaminathan, S., Yamane, H., and Peters, R. J., Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.
Q. Wang, Hillwig, M. L., Wu, Y., and Peters, R. J., CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.
J. Guo, Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., and Chen, X., CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.
S. Swaminathan, Morrone, D., Wang, Q., D Fulton, B., and Peters, R. J., CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.
Q. Wang, Hillwig, M. L., and Peters, R. J., CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
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M. Xu, P Wilderman, R., and Peters, R. J., Following evolution's lead to a single residue switch for diterpene synthase product outcome, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007.
F. M. Mann, Xu, M., Davenport, E. K., and Peters, R. J., Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria, Frontiers in microbiology, vol. 3, 2012.
M. Xu, P Wilderman, R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N. M., Coates, R. M., and Peters, R. J., Functional characterization of the rice kaurene synthase-like gene family, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007.
D. M. Hershey, Lu, X., Zi, J., and Peters, R. J., Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014.
W. Gao, Hillwig, M. L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B., and Peters, R. J., A functional genomics approach to tanshinone biosynthesis provides stereochemical insights, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.
M. Xu, Hillwig, M. L., Prisic, S., Coates, R. M., and Peters, R. J., Functional identification of rice syn‐copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products, The Plant Journal, vol. 39, no. 3, pp. 309-318, 2004.
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R. P Wilderman, Xu, M., Jin, Y., Coates, R. M., and Peters, R. J., Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis, Plant physiology, vol. 135, no. 4, pp. 2098-2105, 2004.
D. Morrone, Xu, M., D Fulton, B., Determan, M. K., and Peters, R. J., Increasing complexity of a diterpene synthase reaction with a single residue switch, Journal of the American Chemical Society, vol. 130, no. 16, pp. 5400-5401, 2008.
D. Morrone, Lowry, L., Determan, M. K., Hershey, D. M., Xu, M., and Peters, R. J., Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering, Applied microbiology and biotechnology, vol. 85, no. 6, pp. 1893-1906, 2010.
K. Zhou, Gao, Y., Hoy, J. A., Mann, F. M., Honzatko, R. B., and Peters, R. J., Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6840-6850, 2012.
K. Zhou and Peters, R. J., Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants, Phytochemistry, vol. 70, no. 3, pp. 366-369, 2009.
F. M. Mann and Peters, R. J., Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis, Med. Chem. Commun., vol. 3, no. 8, pp. 899-904, 2012.

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