Publications

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Book Chapter
R. J. Peters, Gibberellin phytohormone metabolism, in Isoprenoid Synthesis in Plants and Microorganisms, Springer New York, 2013, pp. 233-249.
Journal Article
M. Köksal, Potter, K., Peters, R. J., and Christianson, D. W., 1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis, Biochimica et Biophysica Acta (BBA), vol. 1840, no. 1, pp. 184-190, 2014.
A. Roy, Roberts, F. G., P Wilderman, R., Zhou, K., Peters, R. J., and Coates, R. M., 16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana, Journal of the American Chemical Society, vol. 129, no. 41, pp. 12453-12460, 2007.
R. J. Peters and Croteau, R. B., Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate, Biochemistry, vol. 41, no. 6, pp. 1836-1842, 2002.
R. J. Peters and Croteau, R. B., Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement, Proceedings of the National Academy of Sciences, vol. 99, no. 2, pp. 580-584, 2002.
R. J. Peters, Flory, J. E., Jetter, R., Ravn, M. M., Lee, H. - J., Coates, R. M., and Croteau, R. B., Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the “pseudomature” recombinant enzyme, Biochemistry, vol. 39, no. 50, pp. 15592-15602, 2000.
L. D. Hernandez, Peters, R. J., Delos, S. E., Young, J. A. T., Agard, D. A., and White, J. M., Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein, The Journal of cell biology, vol. 139, no. 6, pp. 1455-1464, 1997.
R. J. Peters and Croteau, R. B., Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases, Archives of biochemistry and biophysics, vol. 417, no. 2, pp. 203-211, 2003.
R. J. Peters, Ravn, M. M., Coates, R. M., and Croteau, R. B., Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites, Journal of the American Chemical Society, vol. 123, no. 37, pp. 8974-8978, 2001.
R. J. Peters, Carter, O. A., Zhang, Y., Matthews, B. W., and Croteau, R. B., Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations, Biochemistry, vol. 42, no. 9, pp. 2700-2707, 2003.
A. J. Jackson, Hershey, D. M., Chesnut, T., Xu, M., and Peters, R. J., Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization, Phytochemistry, vol. 103, pp. 13-21, 2014.
E. A. Schmelz, Huffaker, A., Sims, J. W., Christensen, S. A., Lu, X., Okada, K., and Peters, R. J., Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins, The Plant Journal, vol. 79, no. 4, pp. 659-678, 2014.
F. M. Mann, Prisic, S., Hu, H., Xu, M., Coates, R. M., and Peters, R. J., Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis IMPLICATIONS FOR TUBERCULOSIS, Journal of Biological Chemistry, vol. 284, no. 35, pp. 23574-23579, 2009.
M. Xu, Hillwig, M. L., Lane, A. L., Tiernan, M. S., Moore, B. S., and Peters, R. J., Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola, Journal of natural products, vol. 77, no. 9, pp. 2144-2147, 2014.
J. Zi and Peters, R. J., Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae, Organic & biomolecular chemistry, vol. 11, no. 44, pp. 7650-7652, 2013.
Q. Wang, Hillwig, M. L., Okada, K., Yamazaki, K., Wu, Y., Swaminathan, S., Yamane, H., and Peters, R. J., Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.
Q. Wang, Hillwig, M. L., Wu, Y., and Peters, R. J., CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.
J. Guo, Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., and Chen, X., CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.
S. Swaminathan, Morrone, D., Wang, Q., D Fulton, B., and Peters, R. J., CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.
Q. Wang, Hillwig, M. L., and Peters, R. J., CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
M. L. Hillwig, Mann, F. M., and Peters, R. J., Diterpenoid biopolymers: new directions for renewable materials engineering, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011.
M. L. Hillwig, Xu, M., Toyomasu, T., Tiernan, M. S., Wei, G., Cui, G., Huang, L., and Peters, R. J., Domain loss has independently occurred multiple times in plant terpene synthase evolution, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011.
F. M. Mann, Xu, M., Chen, X., D Fulton, B., Russell, D. G., and Peters, R. J., Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis, Journal of the American Chemical Society, vol. 131, no. 48, pp. 17526-17527, 2009.
L. Zu, Xu, M., Lodewyk, M. W., Cane, D. E., Peters, R. J., and Tantillo, D. J., Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry, Journal of the American Chemical Society, vol. 134, no. 28, pp. 11369-11371, 2012.
K. Zhou and Peters, R. J., Electrostatic effects on (di)terpene synthase product outcome, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011.
M. Xu, P Wilderman, R., and Peters, R. J., Following evolution's lead to a single residue switch for diterpene synthase product outcome, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007.
F. M. Mann, Xu, M., Davenport, E. K., and Peters, R. J., Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria, Frontiers in microbiology, vol. 3, 2012.
M. Xu, P Wilderman, R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N. M., Coates, R. M., and Peters, R. J., Functional characterization of the rice kaurene synthase-like gene family, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007.
D. M. Hershey, Lu, X., Zi, J., and Peters, R. J., Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014.
W. Gao, Hillwig, M. L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B., and Peters, R. J., A functional genomics approach to tanshinone biosynthesis provides stereochemical insights, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.
M. Xu, Hillwig, M. L., Prisic, S., Coates, R. M., and Peters, R. J., Functional identification of rice syn‐copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products, The Plant Journal, vol. 39, no. 3, pp. 309-318, 2004.
D. Morrone, Chambers, J., Lowry, L., Kim, G., Anterola, A., Bender, K., and Peters, R. J., Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum, FEBS letters, vol. 583, no. 2, pp. 475-480, 2009.
R. P Wilderman, Xu, M., Jin, Y., Coates, R. M., and Peters, R. J., Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis, Plant physiology, vol. 135, no. 4, pp. 2098-2105, 2004.
D. Morrone, Xu, M., D Fulton, B., Determan, M. K., and Peters, R. J., Increasing complexity of a diterpene synthase reaction with a single residue switch, Journal of the American Chemical Society, vol. 130, no. 16, pp. 5400-5401, 2008.
D. Morrone, Lowry, L., Determan, M. K., Hershey, D. M., Xu, M., and Peters, R. J., Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering, Applied microbiology and biotechnology, vol. 85, no. 6, pp. 1893-1906, 2010.
K. Zhou, Gao, Y., Hoy, J. A., Mann, F. M., Honzatko, R. B., and Peters, R. J., Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6840-6850, 2012.
K. Zhou and Peters, R. J., Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants, Phytochemistry, vol. 70, no. 3, pp. 366-369, 2009.
F. M. Mann and Peters, R. J., Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis, Med. Chem. Commun., vol. 3, no. 8, pp. 899-904, 2012.
F. M. Mann, VanderVen, B. C., and Peters, R. J., Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis, Molecular microbiology, vol. 79, no. 6, pp. 1594-1601, 2011.
M. M. Ravn, Peters, R. J., Coates, R. M., and Croteau, R., Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates, Journal of the American Chemical Society, vol. 124, no. 24, pp. 6998-7006, 2002.
R. J. Peters and Croteau, R. B., Metabolic engineering of plant secondary metabolism, Handbook of plant biotechnology, 2004.
A. Cyr, P Wilderman, R., Determan, M., and Peters, R. J., A modular approach for facile biosynthesis of labdane-related diterpenes, Journal of the American Chemical Society, vol. 129, no. 21, pp. 6684-6685, 2007.
O. A. Carter, Peters, R. J., and Croteau, R., Monoterpene biosynthesis pathway construction in Escherichia coli, Phytochemistry, vol. 64, no. 2, pp. 425-433, 2003.
S. Mafu, Hillwig, M. L., and Peters, R. J., A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii, ChemBioChem, vol. 12, no. 13, pp. 1984-1987, 2011.
K. Potter, Criswell, J., Zi, J., Stubbs, A., and Peters, R. J., Novel Product Chemistry from Mechanistic Analysis of ent‐Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis, Angewandte Chemie International Edition, vol. 53, pp. 7198-7202, 2014.
Y. Wu, Hillwig, M. L., Wang, Q., and Peters, R. J., Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7, FEBS letters, vol. 585, no. 21, pp. 3446-3451, 2011.
R. J. Peters, Shiau, A. K., Sohl, J. L., D Anderson, E., Tang, G., Silen, J. L., and Agard, D. A., Pro region C-terminus: protease active site interactions are critical in catalyzing the folding of α-lytic protease, Biochemistry, vol. 37, no. 35, pp. 12058-12067, 1998.
S. Prisic, Xu, J., Coates, R. M., and Peters, R. J., Probing the role of the DXDD motif in class II diterpene cyclases, ChemBioChem, vol. 8, no. 8, pp. 869-874, 2007.
S. Prisic, Xu, M., P Wilderman, R., and Peters, R. J., Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions, Plant physiology, vol. 136, no. 4, pp. 4228-4236, 2004.
H. Kato-Noguchi and Peters, R. J., The role of momilactones in rice allelopathy, Journal of chemical ecology, vol. 39, no. 2, pp. 175-185, 2013.

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