Publications
, “α-Lytic protease precursor: Characterization of a structured folding intermediate”, Biochemistry, vol. 38, no. 15, pp. 4728-4735, 1999.
, “An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase”, Archives of biochemistry and biophysics, vol. 448, no. 1, pp. 133-140, 2006.
, “Uncovering the complex metabolic network underlying diterpenoid phytoalexin biosynthesis in rice and other cereal crop plants”, Phytochemistry, vol. 67, no. 21, pp. 2307-2317, 2006.
, “Two rings in them all: the labdane-related diterpenoids”, Natural product reports, vol. 27, no. 11, pp. 1521-1530, 2010.
, “To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism”, Annual review of plant biology, vol. 65, pp. 259-286, 2014.
, “Terpenoid synthase structures: a so far incomplete view of complex catalysis”, Natural product reports, vol. 29, no. 10, pp. 1153-1175, 2012.
, “Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene) and (±)-Tuberculosinol”, Organic letters, vol. 12, no. 11, pp. 2626-2629, 2010.
, “Synergistic substrate inhibition of ent-copalyl diphosphate synthase: a potential feed-forward inhibition mechanism limiting gibberellin metabolism”, Plant physiology, vol. 144, no. 1, pp. 445-454, 2007.
, “Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase”, Nature chemical biology, vol. 7, no. 7, pp. 431-433, 2011.
, “Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (-)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis”, Organic letters, vol. 2, no. 5, pp. 573-576, 2000.
, “The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus”, FEBS letters, vol. 509, no. 2, pp. 161-168, 2001.
, “A single residue switch for Mg2+-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism”, Journal of Biological Chemistry, vol. 285, no. 27, pp. 20558-20563, 2010.
, “A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase”, Journal of the American Chemical Society, vol. 129, no. 51, pp. 15736-15737, 2007.
, “A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase”, Organic letters, vol. 14, no. 23, pp. 5828-5831, 2012.
, “Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis”, FEBS letters, vol. 585, no. 3, pp. 549-554, 2011.
, “The role of momilactones in rice allelopathy”, Journal of chemical ecology, vol. 39, no. 2, pp. 175-185, 2013.
, “Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions”, Plant physiology, vol. 136, no. 4, pp. 4228-4236, 2004.
, “Probing the role of the DXDD motif in class II diterpene cyclases”, ChemBioChem, vol. 8, no. 8, pp. 869-874, 2007.
, “Pro region C-terminus: protease active site interactions are critical in catalyzing the folding of α-lytic protease”, Biochemistry, vol. 37, no. 35, pp. 12058-12067, 1998.
, “Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7”, FEBS letters, vol. 585, no. 21, pp. 3446-3451, 2011.
, “Novel Product Chemistry from Mechanistic Analysis of ent‐Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis”, Angewandte Chemie International Edition, vol. 53, pp. 7198-7202, 2014.
, “A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii”, ChemBioChem, vol. 12, no. 13, pp. 1984-1987, 2011.
, “Monoterpene biosynthesis pathway construction in Escherichia coli”, Phytochemistry, vol. 64, no. 2, pp. 425-433, 2003.
, “A modular approach for facile biosynthesis of labdane-related diterpenes”, Journal of the American Chemical Society, vol. 129, no. 21, pp. 6684-6685, 2007.
, “Metabolic engineering of plant secondary metabolism”, Handbook of plant biotechnology, 2004.
, “Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates”, Journal of the American Chemical Society, vol. 124, no. 24, pp. 6998-7006, 2002.
, “Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis”, Molecular microbiology, vol. 79, no. 6, pp. 1594-1601, 2011.
, “Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis”, Med. Chem. Commun., vol. 3, no. 8, pp. 899-904, 2012.
, “Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants”, Phytochemistry, vol. 70, no. 3, pp. 366-369, 2009.
, “Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis”, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6840-6850, 2012.
, “Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering”, Applied microbiology and biotechnology, vol. 85, no. 6, pp. 1893-1906, 2010.
, “Increasing complexity of a diterpene synthase reaction with a single residue switch”, Journal of the American Chemical Society, vol. 130, no. 16, pp. 5400-5401, 2008.
, “Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis”, Plant physiology, vol. 135, no. 4, pp. 2098-2105, 2004.
, “Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum”, FEBS letters, vol. 583, no. 2, pp. 475-480, 2009.
, “Functional identification of rice syn‐copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products”, The Plant Journal, vol. 39, no. 3, pp. 309-318, 2004.
, “A functional genomics approach to tanshinone biosynthesis provides stereochemical insights”, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.
, “Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia”, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014.
, “Functional characterization of the rice kaurene synthase-like gene family”, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007.
, “Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria”, Frontiers in microbiology, vol. 3, 2012.
, “Following evolution's lead to a single residue switch for diterpene synthase product outcome”, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007.
, “Electrostatic effects on (di)terpene synthase product outcome”, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011.
, “Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry”, Journal of the American Chemical Society, vol. 134, no. 28, pp. 11369-11371, 2012.
, “Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis”, Journal of the American Chemical Society, vol. 131, no. 48, pp. 17526-17527, 2009.
, “Domain loss has independently occurred multiple times in plant terpene synthase evolution”, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011.
, “Diterpenoid biopolymers: new directions for renewable materials engineering”, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011.
, “CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice”, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
, “CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice”, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.
, “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts”, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.
, “CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism”, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.
, “Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster”, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.