Publications

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Journal Article
E. D Anderson, Peters, R. J., Wilk, B., and Agard, D. A., α-Lytic protease precursor: Characterization of a structured folding intermediate, Biochemistry, vol. 38, no. 15, pp. 4728-4735, 1999.
D. Morrone, Jin, Y., Xu, M., Choi, S. - Y., Coates, R. M., and Peters, R. J., An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase, Archives of biochemistry and biophysics, vol. 448, no. 1, pp. 133-140, 2006.
R. J. Peters, Uncovering the complex metabolic network underlying diterpenoid phytoalexin biosynthesis in rice and other cereal crop plants, Phytochemistry, vol. 67, no. 21, pp. 2307-2317, 2006.
R. J. Peters, Two rings in them all: the labdane-related diterpenoids, Natural product reports, vol. 27, no. 11, pp. 1521-1530, 2010.
J. Zi, Mafu, S., and Peters, R. J., To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism, Annual review of plant biology, vol. 65, pp. 259-286, 2014.
Y. Gao, Honzatko, R. B., and Peters, R. J., Terpenoid synthase structures: a so far incomplete view of complex catalysis, Natural product reports, vol. 29, no. 10, pp. 1153-1175, 2012.
N. Maugel, Mann, F. M., Hillwig, M. L., Peters, R. J., and Snider, B. B., Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene) and (±)-Tuberculosinol, Organic letters, vol. 12, no. 11, pp. 2626-2629, 2010.
S. Prisic and Peters, R. J., Synergistic substrate inhibition of ent-copalyl diphosphate synthase: a potential feed-forward inhibition mechanism limiting gibberellin metabolism, Plant physiology, vol. 144, no. 1, pp. 445-454, 2007.
M. Köksal, Hu, H., Coates, R. M., Peters, R. J., and Christianson, D. W., Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase, Nature chemical biology, vol. 7, no. 7, pp. 431-433, 2011.
M. M. Ravn, Coates, R. M., Flory, J. E., Peters, R. J., and Croteau, R., Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (-)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis, Organic letters, vol. 2, no. 5, pp. 573-576, 2000.
M. Tonelli, Peters, R. J., James, T. L., and Agard, D. A., The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus, FEBS letters, vol. 509, no. 2, pp. 161-168, 2001.
F. M. Mann, Prisic, S., Davenport, E. K., Determan, M. K., Coates, R. M., and Peters, R. J., A single residue switch for Mg2+-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism, Journal of Biological Chemistry, vol. 285, no. 27, pp. 20558-20563, 2010.
R. P Wilderman and Peters, R. J., A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase, Journal of the American Chemical Society, vol. 129, no. 51, pp. 15736-15737, 2007.
J. Criswell, Potter, K., Shephard, F., Beale, M. H., and Peters, R. J., A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase, Organic letters, vol. 14, no. 23, pp. 5828-5831, 2012.
F. M. Mann, Thomas, J. A., and Peters, R. J., Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis, FEBS letters, vol. 585, no. 3, pp. 549-554, 2011.
H. Kato-Noguchi and Peters, R. J., The role of momilactones in rice allelopathy, Journal of chemical ecology, vol. 39, no. 2, pp. 175-185, 2013.
S. Prisic, Xu, M., P Wilderman, R., and Peters, R. J., Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions, Plant physiology, vol. 136, no. 4, pp. 4228-4236, 2004.
S. Prisic, Xu, J., Coates, R. M., and Peters, R. J., Probing the role of the DXDD motif in class II diterpene cyclases, ChemBioChem, vol. 8, no. 8, pp. 869-874, 2007.
R. J. Peters, Shiau, A. K., Sohl, J. L., D Anderson, E., Tang, G., Silen, J. L., and Agard, D. A., Pro region C-terminus: protease active site interactions are critical in catalyzing the folding of α-lytic protease, Biochemistry, vol. 37, no. 35, pp. 12058-12067, 1998.
Y. Wu, Hillwig, M. L., Wang, Q., and Peters, R. J., Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7, FEBS letters, vol. 585, no. 21, pp. 3446-3451, 2011.
K. Potter, Criswell, J., Zi, J., Stubbs, A., and Peters, R. J., Novel Product Chemistry from Mechanistic Analysis of ent‐Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis, Angewandte Chemie International Edition, vol. 53, pp. 7198-7202, 2014.
S. Mafu, Hillwig, M. L., and Peters, R. J., A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii, ChemBioChem, vol. 12, no. 13, pp. 1984-1987, 2011.
O. A. Carter, Peters, R. J., and Croteau, R., Monoterpene biosynthesis pathway construction in Escherichia coli, Phytochemistry, vol. 64, no. 2, pp. 425-433, 2003.
A. Cyr, P Wilderman, R., Determan, M., and Peters, R. J., A modular approach for facile biosynthesis of labdane-related diterpenes, Journal of the American Chemical Society, vol. 129, no. 21, pp. 6684-6685, 2007.
R. J. Peters and Croteau, R. B., Metabolic engineering of plant secondary metabolism, Handbook of plant biotechnology, 2004.
M. M. Ravn, Peters, R. J., Coates, R. M., and Croteau, R., Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates, Journal of the American Chemical Society, vol. 124, no. 24, pp. 6998-7006, 2002.
F. M. Mann, VanderVen, B. C., and Peters, R. J., Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis, Molecular microbiology, vol. 79, no. 6, pp. 1594-1601, 2011.
F. M. Mann and Peters, R. J., Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis, Med. Chem. Commun., vol. 3, no. 8, pp. 899-904, 2012.
K. Zhou and Peters, R. J., Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants, Phytochemistry, vol. 70, no. 3, pp. 366-369, 2009.
K. Zhou, Gao, Y., Hoy, J. A., Mann, F. M., Honzatko, R. B., and Peters, R. J., Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6840-6850, 2012.
D. Morrone, Lowry, L., Determan, M. K., Hershey, D. M., Xu, M., and Peters, R. J., Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering, Applied microbiology and biotechnology, vol. 85, no. 6, pp. 1893-1906, 2010.
D. Morrone, Xu, M., D Fulton, B., Determan, M. K., and Peters, R. J., Increasing complexity of a diterpene synthase reaction with a single residue switch, Journal of the American Chemical Society, vol. 130, no. 16, pp. 5400-5401, 2008.
R. P Wilderman, Xu, M., Jin, Y., Coates, R. M., and Peters, R. J., Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis, Plant physiology, vol. 135, no. 4, pp. 2098-2105, 2004.
D. Morrone, Chambers, J., Lowry, L., Kim, G., Anterola, A., Bender, K., and Peters, R. J., Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum, FEBS letters, vol. 583, no. 2, pp. 475-480, 2009.
M. Xu, Hillwig, M. L., Prisic, S., Coates, R. M., and Peters, R. J., Functional identification of rice syn‐copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products, The Plant Journal, vol. 39, no. 3, pp. 309-318, 2004.
W. Gao, Hillwig, M. L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B., and Peters, R. J., A functional genomics approach to tanshinone biosynthesis provides stereochemical insights, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.
D. M. Hershey, Lu, X., Zi, J., and Peters, R. J., Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014.
M. Xu, P Wilderman, R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N. M., Coates, R. M., and Peters, R. J., Functional characterization of the rice kaurene synthase-like gene family, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007.
F. M. Mann, Xu, M., Davenport, E. K., and Peters, R. J., Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria, Frontiers in microbiology, vol. 3, 2012.
M. Xu, P Wilderman, R., and Peters, R. J., Following evolution's lead to a single residue switch for diterpene synthase product outcome, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007.
K. Zhou and Peters, R. J., Electrostatic effects on (di)terpene synthase product outcome, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011.
L. Zu, Xu, M., Lodewyk, M. W., Cane, D. E., Peters, R. J., and Tantillo, D. J., Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry, Journal of the American Chemical Society, vol. 134, no. 28, pp. 11369-11371, 2012.
F. M. Mann, Xu, M., Chen, X., D Fulton, B., Russell, D. G., and Peters, R. J., Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis, Journal of the American Chemical Society, vol. 131, no. 48, pp. 17526-17527, 2009.
M. L. Hillwig, Xu, M., Toyomasu, T., Tiernan, M. S., Wei, G., Cui, G., Huang, L., and Peters, R. J., Domain loss has independently occurred multiple times in plant terpene synthase evolution, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011.
M. L. Hillwig, Mann, F. M., and Peters, R. J., Diterpenoid biopolymers: new directions for renewable materials engineering, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011.
Q. Wang, Hillwig, M. L., and Peters, R. J., CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
S. Swaminathan, Morrone, D., Wang, Q., D Fulton, B., and Peters, R. J., CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.
J. Guo, Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., and Chen, X., CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.
Q. Wang, Hillwig, M. L., Wu, Y., and Peters, R. J., CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.
Q. Wang, Hillwig, M. L., Okada, K., Yamazaki, K., Wu, Y., Swaminathan, S., Yamane, H., and Peters, R. J., Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.

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