Publications

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Book Chapter
R. J. Peters, Gibberellin phytohormone metabolism, in Isoprenoid Synthesis in Plants and Microorganisms, Springer New York, 2013, pp. 233-249.
Journal Article
M. Köksal, Potter, K., Peters, R. J., and Christianson, D. W., 1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis, Biochimica et Biophysica Acta (BBA), vol. 1840, no. 1, pp. 184-190, 2014.
A. Roy, Roberts, F. G., P Wilderman, R., Zhou, K., Peters, R. J., and Coates, R. M., 16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana, Journal of the American Chemical Society, vol. 129, no. 41, pp. 12453-12460, 2007.
R. J. Peters and Croteau, R. B., Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate, Biochemistry, vol. 41, no. 6, pp. 1836-1842, 2002.
R. J. Peters and Croteau, R. B., Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement, Proceedings of the National Academy of Sciences, vol. 99, no. 2, pp. 580-584, 2002.
R. J. Peters, Flory, J. E., Jetter, R., Ravn, M. M., Lee, H. - J., Coates, R. M., and Croteau, R. B., Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the “pseudomature” recombinant enzyme, Biochemistry, vol. 39, no. 50, pp. 15592-15602, 2000.
L. D. Hernandez, Peters, R. J., Delos, S. E., Young, J. A. T., Agard, D. A., and White, J. M., Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein, The Journal of cell biology, vol. 139, no. 6, pp. 1455-1464, 1997.
R. J. Peters and Croteau, R. B., Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases, Archives of biochemistry and biophysics, vol. 417, no. 2, pp. 203-211, 2003.
N. Kitaoka, Lu, X., Yang, B., and Peters, R. J., The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism, Mol Plant, vol. 8, pp. 6-16, 2015.
R. J. Peters, Ravn, M. M., Coates, R. M., and Croteau, R. B., Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites, Journal of the American Chemical Society, vol. 123, no. 37, pp. 8974-8978, 2001.
R. J. Peters, Carter, O. A., Zhang, Y., Matthews, B. W., and Croteau, R. B., Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations, Biochemistry, vol. 42, no. 9, pp. 2700-2707, 2003.
A. J. Jackson, Hershey, D. M., Chesnut, T., Xu, M., and Peters, R. J., Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization, Phytochemistry, vol. 103, pp. 13-21, 2014.
E. A. Schmelz, Huffaker, A., Sims, J. W., Christensen, S. A., Lu, X., Okada, K., and Peters, R. J., Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins, The Plant Journal, vol. 79, no. 4, pp. 659-678, 2014.
J. Zi, Matsuba, Y., Hong, Y. J., Jackson, A. J., Tantillo, D. J., Pichersky, E., and Peters, R. J., Biosynthesis of lycosantalonol, a cis-prenyl derived diterpenoid, J Am Chem Soc, vol. 136, pp. 16951-3, 2014.
Y. Matsuba, Zi, J., Jones, A. D., Peters, R. J., and Pichersky, E., Biosynthesis of the Diterpenoid Lycosantalonol via Nerylneryl Diphosphate in Solanum lycopersicum, PLoS One, vol. 10, p. e0119302, 2015.
K. C. Potter, Zi, J., Hong, Y. J., Schulte, S., Malchow, B., Tantillo, D. J., and Peters, R. J., Blocking Deprotonation with Retention of Aromaticity in a Plant ent-Copalyl Diphosphate Synthase Leads to Product Rearrangement, Angew Chem Int Ed Eng, vol. 55, no. 2, pp. 634-638, 2016.
F. M. Mann, Prisic, S., Hu, H., Xu, M., Coates, R. M., and Peters, R. J., Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis IMPLICATIONS FOR TUBERCULOSIS, Journal of Biological Chemistry, vol. 284, no. 35, pp. 23574-23579, 2009.
M. Xu, Hillwig, M. L., Lane, A. L., Tiernan, M. S., Moore, B. S., and Peters, R. J., Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola, Journal of natural products, vol. 77, no. 9, pp. 2144-2147, 2014.
H. Mao, Liu, J., Ren, F., Peters, R. J., and Wang, Q., Characterization of CYP71Z18 indicates a role in maize zealexin biosynthesis, Phytochemistry, vol. 121, pp. 4-10, 2016.
J. Zi and Peters, R. J., Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae, Organic & biomolecular chemistry, vol. 11, no. 44, pp. 7650-7652, 2013.
Q. Wang, Hillwig, M. L., Okada, K., Yamazaki, K., Wu, Y., Swaminathan, S., Yamane, H., and Peters, R. J., Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.
D. Morrone, Chen, X., Coates, R., and Peters, R., Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis, Biochem. J, vol. 431, pp. 337-344, 2010.
W. Gao, Sun, H. - X., Xiao, H., Cui, G., Hillwig, M. L., Jackson, A., Wang, X., Shen, Y., Zhao, N., and Zhang, L., Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza, BMC genomics, vol. 15, no. 1, p. 73, 2014.
Q. Wang, Hillwig, M. L., Wu, Y., and Peters, R. J., CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.
J. Guo, Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., and Chen, X., CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.
S. Swaminathan, Morrone, D., Wang, Q., D Fulton, B., and Peters, R. J., CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.
Q. Wang, Hillwig, M. L., and Peters, R. J., CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
J. Guo, Ma, X., Cai, Y., Ma, Y., Zhan, Z., Zhou, Y. J., Liu, W., Guan, M., Yang, J., Cui, G., Kang, L., Yang, L., Shen, Y., Tang, J., Lin, H., Ma, X., Jin, B., Liu, Z., Peters, R. J., Zhao, Z. K., and Huang, L., Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones, New Phytol, vol. in press, 2016.
R. Cao, Zhang, Y., Mann, F. M., Huang, C., Mukkamala, D., Hudock, M. P., Mead, M. E., Prisic, S., Wang, K., and Lin, F. ‐Y., Diterpene cyclases and the nature of the isoprene fold, Proteins: Structure, Function, and Bioinformatics, vol. 78, no. 11, pp. 2417-2432, 2010.
M. L. Hillwig, Mann, F. M., and Peters, R. J., Diterpenoid biopolymers: new directions for renewable materials engineering, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011.
M. L. Hillwig, Xu, M., Toyomasu, T., Tiernan, M. S., Wei, G., Cui, G., Huang, L., and Peters, R. J., Domain loss has independently occurred multiple times in plant terpene synthase evolution, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011.
F. M. Mann, Xu, M., Chen, X., D Fulton, B., Russell, D. G., and Peters, R. J., Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis, Journal of the American Chemical Society, vol. 131, no. 48, pp. 17526-17527, 2009.
L. Zu, Xu, M., Lodewyk, M. W., Cane, D. E., Peters, R. J., and Tantillo, D. J., Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry, Journal of the American Chemical Society, vol. 134, no. 28, pp. 11369-11371, 2012.
S. Mafu, Potter, K. C., Hillwig, M. L., Schulte, S., Criswell, J., and Peters, R. J., Efficient heterocyclisation by (di)terpene synthases, Chem Commun (Camb), vol. 51, no. 70, pp. 13485-7, 2015.
K. Zhou and Peters, R. J., Electrostatic effects on (di)terpene synthase product outcome, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011.
X. Lu, Hershey, D. M., Wang, L., Bogdanove, A. J., and Peters, R. J., An ent-kaurene-derived diterpenoid virulence factor from Xanthomonas oryzae pv. oryzicola, New Phytol, vol. 206, pp. 295-302, 2015.
D. Morrone, Hillwig, M., Mead, M., Lowry, L., Fulton, D., and Peters, R., Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals, Biochem. J, vol. 435, pp. 589-595, 2011.
M. Xu, P Wilderman, R., and Peters, R. J., Following evolution's lead to a single residue switch for diterpene synthase product outcome, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007.
Z. Xu, Peters, R. J., Weirather, J., Luo, H., Liao, B., Zhang, X., Zhu, Y., Ji, A., Zhang, B., Hu, S., Au, K. F., Song, J., and Chen, S., Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis, Plant J, vol. 82, pp. 951-61, 2015.
G. Cui, Duan, L., Jin, B., Qian, J., Xue, Z., Shen, G., Snyder, J. H., Song, J., Chen, S., Huang, L., Peters, R. J., and Qi, X., Funcation divergence of diterpene synthases in the medicinal plant Salvia miltiorrhiza Bunge, Plant Physiol, vol. 169, pp. 1607-1618, 2015.
F. M. Mann, Xu, M., Davenport, E. K., and Peters, R. J., Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria, Frontiers in microbiology, vol. 3, 2012.
M. Xu, P Wilderman, R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N. M., Coates, R. M., and Peters, R. J., Functional characterization of the rice kaurene synthase-like gene family, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007.
Y. Wu, Zhou, K., Toyomasu, T., Sugawara, C., Oku, M., Abe, S., Usui, M., Mitsuhashi, W., Chono, M., and Chandler, P. M., Functional characterization of wheat copalyl diphosphate synthases sheds light on the early evolution of labdane-related diterpenoid metabolism in the cereals, Phytochemistry, vol. 84, pp. 40-46, 2012.
K. Zhou, Xu, M., Tiernan, M., Xie, Q., Toyomasu, T., Sugawara, C., Oku, M., Usui, M., Mitsuhashi, W., and Chono, M., Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals, Phytochemistry, vol. 84, pp. 47-55, 2012.
D. M. Hershey, Lu, X., Zi, J., and Peters, R. J., Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014.
W. Gao, Hillwig, M. L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B., and Peters, R. J., A functional genomics approach to tanshinone biosynthesis provides stereochemical insights, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.
M. Xu, Hillwig, M. L., Prisic, S., Coates, R. M., and Peters, R. J., Functional identification of rice syn‐copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products, The Plant Journal, vol. 39, no. 3, pp. 309-318, 2004.
M. Xu, Galhano, R., Wiemann, P., Bueno, E., Tiernan, M., Wu, W., Chung, I. ‐M., Gershenzon, J., Tudzynski, B., and Sesma, A., Genetic evidence for natural product‐mediated plant–plant allelopathy in rice (Oryza sativa), New Phytologist, vol. 193, no. 3, pp. 570-575, 2012.
D. Morrone, Chambers, J., Lowry, L., Kim, G., Anterola, A., Bender, K., and Peters, R. J., Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum, FEBS letters, vol. 583, no. 2, pp. 475-480, 2009.
K. Zingler, Bélanger, Ca, Peters, R., Agard, E., and Young, J. A., Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor., Journal of virology, vol. 69, no. 7, pp. 4261-4266, 1995.

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