Publications

Export 91 results:
2007
A. Roy, Roberts, F. G., P Wilderman, R., Zhou, K., Peters, R. J., and Coates, R. M., 16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana, Journal of the American Chemical Society, vol. 129, no. 41, pp. 12453-12460, 2007.
M. Xu, P Wilderman, R., and Peters, R. J., Following evolution's lead to a single residue switch for diterpene synthase product outcome, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007.
M. Xu, P Wilderman, R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N. M., Coates, R. M., and Peters, R. J., Functional characterization of the rice kaurene synthase-like gene family, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007.
A. Cyr, P Wilderman, R., Determan, M., and Peters, R. J., A modular approach for facile biosynthesis of labdane-related diterpenes, Journal of the American Chemical Society, vol. 129, no. 21, pp. 6684-6685, 2007.
S. Prisic, Xu, J., Coates, R. M., and Peters, R. J., Probing the role of the DXDD motif in class II diterpene cyclases, ChemBioChem, vol. 8, no. 8, pp. 869-874, 2007.
R. P Wilderman and Peters, R. J., A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase, Journal of the American Chemical Society, vol. 129, no. 51, pp. 15736-15737, 2007.
S. Prisic and Peters, R. J., Synergistic substrate inhibition of ent-copalyl diphosphate synthase: a potential feed-forward inhibition mechanism limiting gibberellin metabolism, Plant physiology, vol. 144, no. 1, pp. 445-454, 2007.
2009
F. M. Mann, Prisic, S., Hu, H., Xu, M., Coates, R. M., and Peters, R. J., Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis IMPLICATIONS FOR TUBERCULOSIS, Journal of Biological Chemistry, vol. 284, no. 35, pp. 23574-23579, 2009.
S. Swaminathan, Morrone, D., Wang, Q., D Fulton, B., and Peters, R. J., CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.
F. M. Mann, Xu, M., Chen, X., D Fulton, B., Russell, D. G., and Peters, R. J., Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis, Journal of the American Chemical Society, vol. 131, no. 48, pp. 17526-17527, 2009.
W. Gao, Hillwig, M. L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B., and Peters, R. J., A functional genomics approach to tanshinone biosynthesis provides stereochemical insights, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.
D. Morrone, Chambers, J., Lowry, L., Kim, G., Anterola, A., Bender, K., and Peters, R. J., Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum, FEBS letters, vol. 583, no. 2, pp. 475-480, 2009.
K. Zhou and Peters, R. J., Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants, Phytochemistry, vol. 70, no. 3, pp. 366-369, 2009.
2010
D. Morrone, Chen, X., Coates, R., and Peters, R., Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis, Biochem. J, vol. 431, pp. 337-344, 2010.
R. Cao, Zhang, Y., Mann, F. M., Huang, C., Mukkamala, D., Hudock, M. P., Mead, M. E., Prisic, S., Wang, K., and Lin, F. ‐Y., Diterpene cyclases and the nature of the isoprene fold, Proteins: Structure, Function, and Bioinformatics, vol. 78, no. 11, pp. 2417-2432, 2010.
D. Morrone, Lowry, L., Determan, M. K., Hershey, D. M., Xu, M., and Peters, R. J., Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering, Applied microbiology and biotechnology, vol. 85, no. 6, pp. 1893-1906, 2010.
F. M. Mann, Prisic, S., Davenport, E. K., Determan, M. K., Coates, R. M., and Peters, R. J., A single residue switch for Mg2+-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism, Journal of Biological Chemistry, vol. 285, no. 27, pp. 20558-20563, 2010.
N. Maugel, Mann, F. M., Hillwig, M. L., Peters, R. J., and Snider, B. B., Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene) and (±)-Tuberculosinol, Organic letters, vol. 12, no. 11, pp. 2626-2629, 2010.
R. J. Peters, Two rings in them all: the labdane-related diterpenoids, Natural product reports, vol. 27, no. 11, pp. 1521-1530, 2010.
2011
Q. Wang, Hillwig, M. L., and Peters, R. J., CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.
M. L. Hillwig, Mann, F. M., and Peters, R. J., Diterpenoid biopolymers: new directions for renewable materials engineering, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011.
M. L. Hillwig, Xu, M., Toyomasu, T., Tiernan, M. S., Wei, G., Cui, G., Huang, L., and Peters, R. J., Domain loss has independently occurred multiple times in plant terpene synthase evolution, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011.
K. Zhou and Peters, R. J., Electrostatic effects on (di)terpene synthase product outcome, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011.
D. Morrone, Hillwig, M., Mead, M., Lowry, L., Fulton, D., and Peters, R., Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals, Biochem. J, vol. 435, pp. 589-595, 2011.
F. M. Mann, VanderVen, B. C., and Peters, R. J., Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis, Molecular microbiology, vol. 79, no. 6, pp. 1594-1601, 2011.
S. Mafu, Hillwig, M. L., and Peters, R. J., A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii, ChemBioChem, vol. 12, no. 13, pp. 1984-1987, 2011.
Y. Wu, Hillwig, M. L., Wang, Q., and Peters, R. J., Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7, FEBS letters, vol. 585, no. 21, pp. 3446-3451, 2011.
F. M. Mann, Thomas, J. A., and Peters, R. J., Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis, FEBS letters, vol. 585, no. 3, pp. 549-554, 2011.

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