Within the last two decades, three highly pathogenic human coronaviruses have emerged and caused global economic and public health crises. The Yang Lab strives to elucidate the structures and dynamics of the coronavirus replication-transcription machinery and how they are modulated by various viral and host factors. Through the integration of structural, biochemical, cell biological, and computational approaches, we are revealing the mechanisms and regulation of SARS-CoV-2 RNA synthesis and developing antivirals to battle COVID-19 and potential outbreaks of deadly coronaviruses in the future.
Area of Expertise:
Structure function and assembly of RNA-protein complexes
Noncoding RNA discovery; RNA structure and function
Ph.D., Pharmacology, University of Minnesota Twin Cities (Fang Li Lab), 2015
Postdoctoral Fellow, Yale University/HHMI (Thomas Steitz and Ronald Breaker Labs), 2015–2020