Past Events

Nov

21

BBMB Seminar - Amy Weeks, Assistant Professor, University of Wisconsin; Post- translational modification proteomics in 4D

Nov 21, 2024 - 3:40 PM

to Nov 21, 2024 - 4:40 PM

1414 Molecular Biology Building

Nov

14

BBMB Seminar - Philip Johnson, Professor, York University; Structure-function studies on aptamer-small molecule complexes

Nov 14, 2024 - 3:40 PM

to Nov 14, 2024 - 4:40 PM

1414 Molecular Biology Building

Nov

07

BBMB Seminar - Jerelle Joseph, Assistant Professor, Princeton University; Computational approaches for understanding and engineering biomolecular condensates

Nov 7, 2024 - 3:40 PM

to Nov 7, 2024 - 4:40 PM

1414 Molecular Biology Building

Abstract:

The interior of cells contains numerous components that must be carefully organized in space to fulfill a wide range of biological functions. Unlike the more familiar membrane-enclosed compartments, biomolecular condensates exist predominantly as spherical, liquid-like droplets composed of proteins and nucleic acids. These condensates do not rely on membranes; instead, phase separation has emerged as one of the leading mechanisms to explain their spatial segregation within the cell.

Oct

31

BBMB Seminar - Lena Stecklberg, Assistant Professor, Columbia University; Dynamic viral RNA structures confer programmed exoribonuclease resistance

Oct 31, 2024 - 3:40 PM

to Oct 31, 2024 - 4:40 PM

1414 Molecular Biology Building

Oct

30

BBMB BioWIP Seminar - Ashwini Rangaraj from the GeetuTuteja Lab in the Department of Genetics, Developmental and Cell Biology

Oct 30, 2024 - 9:00 AM

to Oct 30, 2024 - 10:00 AM

Talk Title: “Characterizing a novel regulatory element upstream of matrix metalloproteinase 9 in placental cells”

Oct

24

BBMB Seminar - Marit Nilsen-Hamilton, Professor, Iowa State University; Understanding aptamers and putting them to work

Oct 24, 2024 - 3:40 PM

to Oct 24, 2024 - 4:40 PM

1414 Molecular Biology Building

Oct

17

BBMB Seminar - Greg Martin, Assistant Professor, Iowa State University; Beyond RTS,S: How cryo-EM is enabling next-gen malaria vaccine design

Oct 17, 2024 - 3:40 PM

to Oct 17, 2024 - 4:40 PM

1414 Molecular Biology Building

Oct

16

BBMB BIOWIP Seminar, Dilini Dissanayake - Toward the characterization of functional dynamics in the Human Alkbh1 enzyme

Oct 16, 2024 - 9:00 AM

to Oct 16, 2024 - 10:00 AM

Abstract: Human Alkbh1 is a member of the AlkB family of proteins. Like other AlkB family proteins, hAlkbh1 is a Fe²⁺ and alpha-ketoglutarate-dependent dioxygenase that catalyzes oxidative demethylation of modified nucleotides and amino acids. hAlkbh1 shows activity against six different substrates such as the m⁶A in ssDNA/ bulge or bubble DNA, m³C in DNA/RNA, methylated lysine in histone H2A, m¹A in mitochondrial tRNA for the demethylation, oxidation of m⁵C in mitochondrial tRNA and lyase cleavage of AP sites in DNA. Also, hAlkbh1 has significant involvement in many cancers, metastasis, developmental defects, hypothermia, etc.

Oct

10

BBMB Seminar - Ian Schneider, Associate Professor, Iowa State University; Understanding and Leveraging Cell-mediated Forces during Multi-cue Directional Migration

Oct 10, 2024 - 3:40 PM

to Oct 10, 2024 - 4:40 PM

1414 Molecular Biology Building

Oct

02

BBMB BIOWIP Seminar, Rachel Murphy - Autoinhibition mechanism of autophagy and apoptosis actin regulators WHAMM and JMY

Oct 2, 2024 - 9:00 AM

to Oct 2, 2024 - 10:00 AM

Abstract: Autophagy and apoptosis are essential cellular processes responsible for maintaining cellular and organismal homeostasis. The formation of autophagy-related organelles and apoptosomes is driven by actin polymerization mediated by two pivotal actin regulators, WHAMM and JMY. Both proteins belong to the Wiskott-Aldrich Syndrome protein (WASP) family of actin nucleation promoting factors, containing a C-terminal VCA domain that binds to and activates the Arp2/3 complex to promote actin polymerization. While many of the cellular roles of WHAMM and JMY have been well studied in vivo, the basal state and regulation of both proteins has remained unclear. My project addresses these critical questions by using recombinantly purified proteins and combining biochemical and structural approaches.

Sep

24

BBMB Awards Brunch -- Please RSVP by Sept. 3 if able

Sep 24, 2024 - 9:45 AM

to Sep 24, 2024 - 11:01 AM

Save the date for our annual BBMB Awards Brunch! All members of our BBMB community are invited to attend this fun event, held in the MBB Atrium.

Sep

19

BBMB Seminar - Warren Rouse, Graduate Student, Iowa State University; Deciphering the RNA Secondary Structure Landscape of Human Genes

Sep 19, 2024 - 3:40 PM

to Sep 19, 2024 - 4:40 PM

1414 Molecular Biology Building

Sep

12

BBMB Seminar - Maria Spies, Professor, University of Iowa - Labile multiring architecture of the DNA repair protein RAD52, its many cellular functions, and a potential as an anticancer drug target

Sep 12, 2024 - 3:40 PM

to Sep 12, 2024 - 4:40 PM

1414 Molecular Biology Building

Sep

05

2024 BSRP πMT Research Showcase -- Free and open to all!

Sep 5, 2024 - 3:40 PM

to Sep 5, 2024 - 5:30 PM

The BBMB Summer Undergraduate Research Program (BSRP) celebrates its second year of success with this fun and fast-paced showcase! Eleven undergraduate researchers will share their takeaways in 3-min-14-second lightning talks. (Pi-minute thesis... get it?) Anyone interested in science or communication is encouraged to attend. BSRP was founded by Kristen Johansen (Faculty Advisor) and Claire Kruesel (Director).

Aug

29

BBMB Seminar - Gustavo Macintosh, Professor, Iowa State University; Using flies to uncover hidden functions of lysosome associated membrane proteins

Aug 29, 2024 - 3:40 PM

to Aug 29, 2024 - 4:40 PM

1414 Molecular Biology Building

May

10

BBMB 2024 Graduation Celebration

May 10, 2024 - 3:00 PM

to , -

BBMB 2024 Graduation Celebration

BBMB community: Please join us Friday, May 10th from 3-5 p.m. to celebrate our graduates!

No RSVP required. Enjoy a fun, brief program starting at 3 p.m. in 1414 Molecular Biology Building (featuring Don Beitz, Emcee) followed by a reception in the Atrium. Refreshments provided.

We hope to see you there!

🎈🎈🎈🎈🎈🎈🎈🎈🎈🎈
🎓🎓🎓🎓🎓🎓🎓🎓🎓🎓

May

02

BBMB Seminar - Emma Morrison, Assistant Professor, Medical College of Wisconsin; Deciphering the dynamic language of histones

May 2, 2024 - 3:40 PM

to May 2, 2024 - 4:40 PM

Apr

25

BBMB Seminar - Samuel Butcher, Professor, University of Wisconsin, Madison; Gene silencing driven by unusual RNA structure

Apr 25, 2024 - 3:40 PM

to Apr 25, 2024 - 4:40 PM

Apr

24

BBMB BIOWIP Seminar; Daniel Boesch - Elucidating the assembly and regulation of the Retriever endosomal cargo sorting complex

Apr 24, 2024 - 9:00 AM

to Apr 24, 2024 - 10:00 AM

Abstract: Endosomal recycling is an essential cellular process in maintaining the homeostasis of plasma membrane (PM) proteins crucial for cell signaling and survival. This process is regulated by the cargo sorting complex Retriever, which directs specific endocytosed PM proteins (cargoes) from endosomes back to the cell membrane. Comprising VPS35L, VPS26C, and VPS29, Retriever partners with various protein assemblies, including the COMMD-CCDC22-CCDC93 (CCC) complex for endosomal lipid regulation, the sorting nexin SNX17 for cargo recognition, and the WASH complex for endosomal actin polymerization. The mechanisms underlying Retriever assembly and its interactions with regulatory factors have remained elusive.

Apr

18

BBMB Seminar - Yogesh Gupta, Associate Professor, University of Texas Health Science Center San Antonio; Structural and mechanistic insights into 2’-O methylation of SARS-CoV-2 mRNA

Apr 18, 2024 - 3:40 PM

to Apr 18, 2024 - 4:40 PM